KMID : 0387420130240030281
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Korean Society of Oriental Neuropsychiatry 2013 Volume.24 No. 3 p.281 ~ p.292
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Antidepressant-like Effects of the Gastrodia elata Bl Extract in Mice
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Hong Soon-Sang
Cho Seung-Hun
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Abstract
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Objectives: A growing body of evidence has suggested that the dysfunction of glutamatergic systems plays a pivotal role in major depressive disorder (MDD). This study was performed to investigate the antidepressant-like effects of the ethanolic extract of Gastrodia elata Bl (GE) in mouse models and to investigate the role of ${\alpha}$ ¼ö½Ä À̹ÌÁö-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors in producing these antidepressant-like effects.
Methods: The forced swim test (FST) and tail suspension test (TST) were used to investigate GE¡¯s behavioral effects in mice. Additional biochemical and behavioral experiments with NBQX, an AMPA receptor antagonist, were undertaken to determine whether the antidepressant-like properties of GE are involved in AMPA receptor throughput.
Results: Oral administration of GE extract (1,600 mg/kg) 1h prior to testing significantly reduced the immobility times in the FST and TST. These antidepressant-like effects of GE extract were increased dose-dependently. Pre-treatment with NBQX significantly attenuated the reduction in immobility time induced by the GE extract in the FST and TST.
Conclusions: The ethanolic extract of GE may exert antidepressant-like effects with involvement of AMPA receptor.
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KEYWORD
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¥á-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), Antidepressant, Gastrodia elata Bl (GE), Forced swim test (FST), Tail suspension test (TST), Depression, Glutamate,
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